Aromatase

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Also Known As:

CYP19; Androstenedione Aromatase; CYP 19; CYP19 Protein; Cytochrome P450 19; Estrogen Synthase; Estrogen Synthetase; P450AROM; Aromatase, Androstenedione; Cytochrome P 450 CYP19; Protein, CYP19; Cytochrome P-450 CYP19; Cytochrome P-450(AROM)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 19: 20
        Aromatase: 2849
        Steroid Hydroxylases: 11
        Aromatase: 2849
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 19: 20
      - Aromatase: 2849
    - Steroid Hydroxylases: 11
      - Aromatase: 2849
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 19: 20
        Aromatase: 2849
        Steroid Hydroxylases: 11
        Aromatase: 2849

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Disease

Drug/Important Bio-Agent (IBA)